3-Thiophenacetic acid → N-[(3thienyl)acetyl]alanine Iso-butyl Ester

HRID 987819Notes

Reaction equation

HRID 987819 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]([CH2:6][C:7]([OH:9])=O)=[CH:2]1.[CH2:10]([O:14][C:15](=[O:19])[C@H:16]([CH3:18])[NH2:17])[CH:11]([CH3:13])[CH3:12]>>[CH2:10]([O:14][C:15](=[O:19])[C@H:16]([CH3:18])[NH:17][C:7](=[O:9])[CH2:6][C:3]1[CH:4]=[CH:5][S:1][CH:2]=1)[CH:11]([CH3:13])[CH3:12]

Participants

3

Reactant 2

HCID 234043-Thiophenacetic acidHCID 137435562-methylpropyl (2S)-2-aminopropanoate

Product 1

HCID 53969374N-[(3thienyl)acetyl]alanine Iso-butyl Ester

Procedure

Following General Procedure BI above, and using 3-thiopheneacetic acid (Aldrich) and alanine iso-butyl ester (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-26fcb3908fff4780b93fb9ac05d2604a
Source dataset
uspto-grants-2003_10
Patent number
US06632811B2

Reaction notes

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