反应详情

1.45 g (13.9 mmol) of neopentylglycol and 88 mg (0.46 mmol) of p-toluenesulfonic acid monohydrate were added to a solution of 1.25 g (4.63 mmol) of 4-benzyloxy-3-propoxybenzaldehyde in 50 ml of toluene and then refluxed for 1 hour under a water separator. Thereafter, the reaction mixture was cooled to room temperature and partitioned between toluene and a saturated sodium bicarbonate solution, and the organic phase was washed several times with water, dried over magnesium sulfate, filtered and evaporated down. Crystallization of the residue from 10 ml of diethyl ether gave 1.07 g of 2-(4-benzyloxy-3-propoxyphenyl)-5,5-dimethyl-1,3-dioxane.

1. temperaturerefluxed for 1 hour under a water separator
2. custompartitioned between toluene
3. washa saturated sodium bicarbonate solution, and the organic phase was washed several times with water
4. dry with materialdried over magnesium sulfate
5. filtrationfiltered
6. customevaporated down
7. customCrystallization of the residue from 10 ml of diethyl ether