反应详情

A mixture of 1.26 g (4.74 mmol) of 4-(5,5-dimethyl-1,3-dioxan-2-yl)-2-propoxyphenol, 20 ml of toluene and 20 ml of formic acid was vigorously stirred for 2 hours at room temperature. Thereafter, the reaction mixture was partitioned between toluene and water and the organic phase was washed several times with water, dried over magnesium sulfate, filtered and evaporated down. Crystallization of the residue from a mixture of 10 ml of diethyl ether and 20 ml of hexane gave 0.78 mg of 4-hydroxy-3-propoxybenzaldehyde.

1. customThereafter, the reaction mixture was partitioned between toluene and water
2. washthe organic phase was washed several times with water
3. dry with materialdried over magnesium sulfate
4. filtrationfiltered
5. customevaporated down
6. customCrystallization of the residue
7. additionfrom a mixture of 10 ml of diethyl ether and 20 ml of hexane