m-Chloroperbenzoic acid → HCID 69853707, compound

Participants

Reaction Steps

A solution of 2-{2-hydroxy-3-[2-methanesulfonylamino-3-(naphthalen-2-sulfinyl)-propionylamino]-4-phenyl-butyl}-5-methoxy-cyclohexanecarboxylic acid tert-butylamide in dichloromethane (2 ml) was treated with a solution of meta-chloroperbenzoic acid (13 mg) in dichloromethane (1 ml) and the reaction mixture stirred at room temperature for 2 hours. The solution was then washed with 5% aqueous sodium hydrogen carbonate solution, dried (anhydrous magnesium sulfate) and concentrated in vacuo to give 2-{2-hydroxy-3-[2-methanesulfonylamino-3-(naphthalen-2-sulfonyl)-propionylamino]-4-phenyl-butyl}-5-methoxy-cyclohexanecarboxylic acid tert-butylamide (23 mg, 92%) as a white foam. Mass spectrum, 717 [M+H]+.

Provenance & Evidence