Sulfuric Acid → HCID 2724782, compound

Participants

Reaction Steps

20 ml (375 mmol; 1.03 eq) of concentrated sulphuric acid are added dropwise to 65 g of D-glucose (361 mmol; 1 eq) and 85 ml (820 mmol ; 2.27 eq) of cyclohexanone in 50 ml of 1,4-dioxane (587 mmol; 1.62 eq) at ambient temperature. Once the addition is complete, after 30 minutes, the product precipitates from the reaction medium. The precipitate is broken up, filtered off and washed with water. The crude product is then purified by recrystallisation from cyclohexane to give to 104 grams of 1,2: 5,6-di-O-cyclohexylidene-α-D-glucofuranose.

Provenance & Evidence