HCID 513971, compound → HCID 513930, compound

HRID 987944Notes

Reaction equation

HRID 987944 reaction equation
C(OC(=O)[NH:7][C@H:8]([C:20](=[O:43])[NH:21][CH2:22][CH2:23][CH2:24][C@H:25]([N:28]([S:33]([C:36]1[CH:41]=[CH:40][C:39]([NH2:42])=[CH:38][CH:37]=1)(=[O:35])=[O:34])[CH2:29][CH:30]([CH3:32])[CH3:31])[CH2:26][OH:27])[CH2:9][C:10]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:13]=[CH:12][CH:11]=1)(C)(C)C.N[C@@H](CC1C=CC2C(=CC=CC=2)C=1)C(NCCCC[C@H](N(S(C1C=CC(N)=CC=1)(=O)=O)CC(C)C)CO)=O>>[NH2:7][C@@H:8]([CH2:9][C:10]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:13]=[CH:12][CH:11]=1)[C:20]([NH:21][CH2:22][CH2:23][CH2:24][C@H:25]([N:28]([S:33]([C:36]1[CH:37]=[CH:38][C:39]([NH2:42])=[CH:40][CH:41]=1)(=[O:35])=[O:34])[CH2:29][CH:30]([CH3:32])[CH3:31])[CH2:26][OH:27])=[O:43]

Participants

3

Reactant 2

HCID 513971HCID 513971, compoundHCID 12986169HCID 12986169, compound

Product 1

HCID 513930HCID 513930, compound

Procedure

The title compound was prepared from (1S,4S)-(1-{4-[(4-amino-benzenesulfonyl)-isobutyl-amino]-5-hydroxy-pentylcarbamoyl}-2-naphthalen-1-yl-ethyl)-carbamic acid tert-butyl ester as described for the preparation of (2S,5S)-2-amino-N-{5-[(4-amino-benzenesulfonyl)-isobutyl-amino]-6-hydroxy-hexyl}-3-naphthalen-2-yl-propionamide (example 49). The final product was obtained in 94% yield.

Sources & evidence

ORD record
ord-1a2d0842c44e498a876a0a1b27392710
Source dataset
uspto-grants-2003_10
Patent number
US06632816B1

Reaction notes

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