HRID987974

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)CN([C@H](CO)CCCCNC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)N1CCOCC1)S(=O)(=O)c1ccc(N)c(Cl)c1

HCID513966

未命名化合物

结构：COC(=O)N[C@H](C(=O)O)C(c1ccccc1)c1ccccc1

HCID10017620

未命名化合物

PRODUCTS

生成物

结构：COC(=O)N[C@H](C(=O)NCCCC[C@@H](CO)N(CC(C)C)S(=O)(=O)c1ccc(N)c(Cl)c1)C(c1ccccc1)c1ccccc1

HCID513972

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from (1S)4-amino-N-(5-amino-1-hydroxymethyl-pentyl)-3-chloro-N-isobutyl-benzenesulfonamide (XII) (example 44, step B) as described in general procedure B using (2S)-2-methoxycarbonylamino-3,3-diphenyl-propionic acid (see example 34, step A). The final product was obtained in 43% yield (48 mg).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8b22f4b3117340f2aecf3895ecaf7793
来源数据集: uspto-grants-2003_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06632816B1
来源说明: uspto-grants-2003_10

反应 SMILES

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]([CH2:43][CH:44]([CH3:46])[CH3:45])[C@H:12]([CH2:41][OH:42])[CH2:13][CH2:14][CH2:15][CH2:16][NH:17]C([C@@H](NC(N2CCOCC2)=O)CC2C3C(=CC=CC=3)C=CC=2)=O)(=[O:10])=[O:9])=[CH:4][C:3]=1[Cl:47].[CH3:48][O:49][C:50]([NH:52][C@@H:53]([CH:57]([C:64]1[CH:69]=[CH:68][CH:67]=[CH:66][CH:65]=1)[C:58]1[CH:63]=[CH:62][CH:61]=[CH:60][CH:59]=1)[C:54](O)=[O:55])=[O:51]>>[CH3:48][O:49][C:50](=[O:51])[NH:52][C@H:53]([C:54](=[O:55])[NH:17][CH2:16][CH2:15][CH2:14][CH2:13][C@H:12]([N:11]([S:8]([C:5]1[CH:6]=[CH:7][C:2]([NH2:1])=[C:3]([Cl:47])[CH:4]=1)(=[O:10])=[O:9])[CH2:43][CH:44]([CH3:45])[CH3:46])[CH2:41][OH:42])[CH:57]([C:64]1[CH:65]=[CH:66][CH:67]=[CH:68][CH:69]=1)[C:58]1[CH:63]=[CH:62][CH:61]=[CH:60][CH:59]=1