Sulfuric Acid → Ethyl 3-(3-bromo-4-hydroxyphenyl)acrylate

HRID 988032Notes

Reaction equation

HRID 988032 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH:5]=[CH:6][C:7]=1[O:8]COC.S(=O)(=O)(O)O>>[Br:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH:5]=[CH:6][C:7]=1[OH:8]

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 69794021Ethyl 3-(3-bromo-4-methoxymethoxyphenyl)acrylate

Product 1

HCID 69793988Ethyl 3-(3-bromo-4-hydroxyphenyl)acrylateYield 70.9%

Procedure

In a manner similar to that of Example 2(g), by reaction of 10.1 g (20.3 mmol) of ethyl 3-(3-bromo-4-methoxymethoxyphenyl)acrylate obtained in Example 2(c) with 5.4 ml (102 mmol) of 98% sulfuric acid, 3.9 g of ethyl 3-(3-bromo-4-hydroxyphenyl)acrylate (49%) were obtained in the form of a white powder having a melting point of 112°-3° C.

Sources & evidence

ORD record
ord-79bf1acec2b641ea82b5cb969ff4c799
Source dataset
uspto-grants-2003_10
Patent number
US06632963B1

Reaction notes

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