L-Tyrosine → HCID 18007097, compound

Participants

Reaction Steps

A mixture of 4-chloro-7,8-dimethoxyimidazo[1,5-a]quinoxaline, prepared as described in U.S. application Ser. No. 09/097,338, “Imidazoquinoxaline Protein Tyrosine Kinase Inhibitors,” filed by Joel C. Barrish et al. concurrently herewith (Attorney Docket No. QA202b) (20 mg, 0.076 mmol), potassium carbonate (52 mg, 0.38 mmol) and 2-chloro-6-methylphenol (13 mg, 0.091 mmol) in 0.5 mL of dry DMF was heated at 80° C. overnight. Upon cooling, the solvent was removed under reduced pressure and the residue was purified by preparative HPLC to give 9.0 mg of the title compound as a tan solid. HPLC Ret. time=4.075 min (HPLC Conditions: 0% B to 100% B; 4 minute gradient; 2 minute hold; 4 mL/min.; 254 nm; YMC S5 C18 Rapid Resolution column 4.6×50 mm; A: 90% H2O−10% MeOH−0.2% H3PO4; B: 10% H2O−90% MeOH−0.2% H3PO4).

Provenance & Evidence