Dicyclohexano-18-crown-6 → HCID 15908227, compound

Participants

Reaction Steps

1.66 mmol of the compound of Example 1 in 40 ml of acetonitrile are stirred overnight at room temperature in the presence of 3.33 mmol of chloromethyl pivalate and a catalytic amount of dicyclohexyl-18-crown-6. The suspension is filtered and the filtrate is evaporated to dryness. The residue is taken up in dichloromethane and the organic phase is washed with a 1N hydrochloric acid solution and then with an aqueous saturated sodium chloride solution. After drying and evaporation, the resulting oily residue is crystallised from a mixture of ether/cyclohexane to yield the expected product.

Provenance & Evidence