HuagongsheHuagongshe Chemistry Print Report · For research reference only
Indole → HCID 9817415, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Indole | HCID 798 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 1-Methyl-2-piperidinemethanol | HCID 89394 | — |
| Reactant | HCID 18007495 | HCID 18007495 | — |
| Reactant | HCID 18007612 | HCID 18007612 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 9817415 | HCID 9817415 | — |
Reaction Steps
6-Bromo-1-(N-methylpiperidin-2-yl)methyl)-1H-indole (220 mg, 57.2%) and 6-bromo-1-(N-methyl-azepan-3-yl)-1H-indole (94 mg, 24.4%); from 6-bromo-1-methanesulfonyl-1H-indole (344 mg, 1.25 mmol) and N-methylpiperidine-2-methanol (395 mg, 2.5 mmol) with NaH (53 mg, 2.2 mmol) and potassium carbonate (325 mg, 2.35 mmol) in toluene (10 mL) at 100° C. overnight.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06635639B2 |
| Source dataset | uspto-grants-2003_10 |
| ORD ID | ord-d747f9622d5044e0ab703af6bd9cc1b2 |
| Source note | uspto-grants-2003_10 |