HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 1,1-dimethylethyl (1S)-2-(6-phenyl-3-pyridazinyl)-2,5-diazabicyclo[2.2.1]heptane-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-Chloro-6-phenylpyridazine | HCID 88515 | — |
| Reactant | (1S,4S)-(-)-2-Boc-2,5-diazabicyclo[2.2.1]heptane | HCID 66592084 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1,1-dimethylethyl (1S)-2-(6-phenyl-3-pyridazinyl)-2,5-diazabicyclo[2.2.1]heptane-5-carboxylate | HCID 90842513 | — |
Reaction Steps
1.0 g (5.0 mmol) of 1,1-dimethylethyl (1S)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate, 1.14 g (6.0 mmol) of 3-chloro-6-phenylpyridazine and 0.84 ml (6.0 mmol) of triethylamine in 45 ml of toluene are introduced into a 100 ml three-necked round-bottomed flask and the mixture is refluxed for 72 h.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06635645B1 |
| Source dataset | uspto-grants-2003_10 |
| ORD ID | ord-383567eca93141abb1e4f44470e65e29 |
| Source note | uspto-grants-2003_10 |