Methyl iodide → HCID 22135430, compound

HRID 988131Notes

Reaction equation

HRID 988131 reaction equation
[CH3:1]I.[NH:3]1[CH2:8][CH2:7][CH:6]([C:9]2[CH:17]=[CH:16][CH:15]=[C:14]3[C:10]=2[CH2:11][C:12](=[O:18])[NH:13]3)[CH2:5][CH2:4]1>C(#N)C.CO>[CH3:1][N:3]1[CH2:4][CH2:5][CH:6]([C:9]2[CH:17]=[CH:16][CH:15]=[C:14]3[C:10]=2[CH2:11][C:12](=[O:18])[NH:13]3)[CH2:7][CH2:8]1

Participants

5

Reactant 2

HCID 6328Methyl iodideHCID 221353964-(Piperidin-4-yl)indolin-2-one

Product 1

HCID 22135430HCID 22135430, compoundYield 70.8%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6342AcetonitrileSolvent

Procedure

Methyl iodide (130.6 mg, 0.92 mmol) was added to a solution of 4-piperidin-4-yl-1,3-dihydroindol-2-one (199 mg, 0.92 mmol) in acetonitrile (10 mL) and methanol (1 mL). The reaction was stirred at room temperature under nitrogen for 2 days. The solvents were removed and the residue was purified on a silica gel column to give 150 mg (70%) of 4-(1-methylpiperidin-4-yl)-1,3-dihydroindol-2-one as a tan solid.

Workup

  1. customThe solvents were removed
  2. customthe residue was purified on a silica gel column

Sources & evidence

ORD record
ord-22e539ea3cf14ca4868e6d5edd460f9b
Source dataset
uspto-grants-2003_10
Patent number
US06635640B2

Reaction notes

Loading…