HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 988149Generated: October 31, 2026
Piperidine → 3-[3-Methyl-4-(piperidine-1-carbonyl)-1H-pyrrol-2-ylmethylene]-4-pyridin-4-yl-1,3-dihydroindol-2-one
https://huagongshe.com/reaction/988149
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 4-Pyridin-4-yl-1,3-dihydro-indol-2-one | HCID 12111581 | — |
| Reactant | 3-methyl-4-(piperidine-1-carbonyl)-1H-pyrrole-2-carbaldehyde | HCID 22135468 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-[3-Methyl-4-(piperidine-1-carbonyl)-1H-pyrrol-2-ylmethylene]-4-pyridin-4-yl-1,3-dihydroindol-2-one | HCID 69188197 | 17% |
Reaction Steps
A mixture of 4-pyridin-4-yl-1,3-dihydroindol-2-one (60 mg, 0.3 mmol), 3-methyl-4-(piperidine-1-carbonyl)-1H-pyrrole-2-carbaldehyde (75 mg, 0.34 mmol) and piperidine (0.14 mL) in ethanol (2 mL) was stirred at 100° C. overnight. The reaction was column chromatographed (2-3% methanol in dichloromethane) to give 20 mg (17%) of the title compound as a yellow orange solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06635640B2 |
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| Source dataset | uspto-grants-2003_10 |
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| ORD ID | ord-cdd8279036824ecda391cd76811dad5e |
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| Source note | uspto-grants-2003_10 |
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