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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 988176Generated: November 2, 2026

4-Oxo-2,4,6,7-tetrahydropyrano[3,4-C]pyrrole-1-carbaldehyde → HCID 49823029, compound

https://huagongshe.com/reaction/988176

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Oxo-2,4,6,7-tetrahydropyrano[3,4-C]pyrrole-1-carbaldehydeHCID 9834049—
Reactant4-(Piperidin-4-yl)indolin-2-oneHCID 22135396—
CatalystPiperidineHCID 8082—
SolventEthanolHCID 702—
ProductHCID 49823029HCID 4982302928%

Reaction Steps

A mixture of 4-piperidin-4-yl-1,3-dihydroindol-2-one (117 mg, 0.54 mmol), 4-oxo-2,4,6,7-tetrahydropyrano[3,4-c]pyrrole-1-carbaldehyde (89.3 mg, 0.54 mmol) and piperidine (1 drop) in ethanol (3 mL) was stirred at room temperature for 2 days. The precipitate was collected by vacuum filtration, washed with ethanol and dried to give 54.1 mg (28%) of the title compound as a yellow solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06635640B2
Source datasetuspto-grants-2003_10
ORD IDord-0746593f09a14069a7db5e5e964e70ba
Source noteuspto-grants-2003_10