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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 988180Generated: November 2, 2026

Acetic Acid → HCID 69584053, compound

https://huagongshe.com/reaction/988180

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAcetic AcidHCID 176—
ReactantPyrrolidineHCID 31268—
Reactant3-(2-formyl-4,5,6,7-tetrahydro-1H-indol-3-yl)propionic acidHCID 10609002—
Reactant4-(Piperidin-4-yl)indolin-2-oneHCID 22135396—
SolventEthanolHCID 702—
ProductHCID 69584053HCID 69584053—

Reaction Steps

A mixture of 4-piperidin-4-yl-1,3-dihydroindol-2-one (45 mg, 0.2 mmol), 3-(2-formyl-4,5,6,7-tetrahydro-1H-indol-3-yl)-propionic acid (57 mg, 0.23 mmol) and pyrrolidine (0.3 mL) in ethanol (0.5 mL) was heated to reflux for 2 hours. Acetic acid (0.05 mL) was added to the reaction and heating was continued for another 10 minutes. The reaction was cooled and the precipitate which formed was collected by vacuum filtration, washed with ethanol and dried to give the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06635640B2
Source datasetuspto-grants-2003_10
ORD IDord-312db2c8a6d349818b2bc504d560d8dc
Source noteuspto-grants-2003_10