3-[5-(Ethoxycarbonyl)-2-formyl-4-methyl-1H-pyrrol-3-yl]propanoic acid → 4-(2-Carboxyethyl)-3-methyl-5-(2-oxo-4-piperidin-4-yl-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrole-2-carboxylic Acid Ethyl Ester

HRID 988197Notes

Reaction equation

HRID 988197 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]2[CH:15]=[CH:14][CH:13]=[C:12]3[C:8]=2[CH2:9][C:10](=[O:16])[NH:11]3)[CH2:3][CH2:2]1.[CH2:17]([O:19][C:20]([C:22]1[NH:23][C:24]([CH:33]=O)=[C:25]([CH2:28][CH2:29][C:30]([OH:32])=[O:31])[C:26]=1[CH3:27])=[O:21])[CH3:18]>>[CH2:17]([O:19][C:20]([C:22]1[NH:23][C:24]([CH:33]=[C:9]2[C:8]3[C:12](=[CH:13][CH:14]=[CH:15][C:7]=3[CH:4]3[CH2:3][CH2:2][NH:1][CH2:6][CH2:5]3)[NH:11][C:10]2=[O:16])=[C:25]([CH2:28][CH2:29][C:30]([OH:32])=[O:31])[C:26]=1[CH3:27])=[O:21])[CH3:18]

Participants

3

Reactant 2

HCID 152706233-[5-(Ethoxycarbonyl)-2-formyl-4-methyl-1H-pyrrol-3-yl]propanoic acidHCID 221353964-(Piperidin-4-yl)indolin-2-one

Product 1

HCID 249412174-(2-Carboxyethyl)-3-methyl-5-(2-oxo-4-piperidin-4-yl-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrole-2-carboxylic Acid Ethyl Ester

Procedure

4-Piperidin-4-yl-1,3-dihydroindol-2-one (45 mg, 0.2 mmol) was condensed with 4-(2-carboxyethyl)-5-formyl-3-methyl-1H-pyrrole-2-carboxylic acid ethyl ester (55 mg, 0.23 mmol) to give the title compound.

Sources & evidence

ORD record
ord-8a81ac75224b41cf8c0eb776f58eefed
Source dataset
uspto-grants-2003_10
Patent number
US06635640B2

Reaction notes

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