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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 988201Generated: October 25, 2026

4-(Piperidin-4-yl)indolin-2-one → 4-Methyl-5-(2-oxo-4-piperidin-4-yl-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrole-3-carboxylic Acid (pyridin-4-ylmethyl)-amide

https://huagongshe.com/reaction/988201

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Piperidin-4-yl)indolin-2-oneHCID 22135396—
Reactant5-formyl-4-methyl-1H-pyrrole-3-carboxylic acid (pyridin-4-ylmethyl)-amideHCID 85802493—
CatalystPiperidineHCID 8082—
SolventEthanolHCID 702—
Product4-Methyl-5-(2-oxo-4-piperidin-4-yl-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrole-3-carboxylic Acid (pyridin-4-ylmethyl)-amideHCID 24940165—

Reaction Steps

A mixture of 4-piperidin-4-yl-1,3-dihydroindol-2-one (54 mg, 0.25 mmol), 5-formyl-4-methyl-1H-pyrrole-3-carboxylic acid (pyridin-4-ylmethyl)-amide (64 mg, 0.2625 mmol) and piperidine (2 drops) in ethanol (0.5 mL) was stirred at room temperature for 7 days. The precipitate which formed was collected by vacuum filtration, washed with ethanol and dried to give the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06635640B2
Source datasetuspto-grants-2003_10
ORD IDord-dd86f19d7cf24141a9a52102ae8b0414
Source noteuspto-grants-2003_10