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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 988205Generated: October 27, 2026

3,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrole-2-carbaldehyde → 3-[3,5-Dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrol-2-ylmethylene]-4-pyrimidin-5-yl-1,3-dihydroindol-2-one

https://huagongshe.com/reaction/988205

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrole-2-carbaldehydeHCID 12111582—
Reactant4-Pyrimidin-5-yl-1,3-dihydroindol-2-oneHCID 22135400—
Product3-[3,5-Dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrol-2-ylmethylene]-4-pyrimidin-5-yl-1,3-dihydroindol-2-oneHCID 24942408—

Reaction Steps

4-Pyrimidin-5-yl-1,3-dihydroindol-2-one (53 mg, 0.25 mmol) was condensed with 3, 5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrole-2-carbaldehyde (69 mg, 0.275 mmol) to give the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06635640B2
Source datasetuspto-grants-2003_10
ORD IDord-e11adebf5529458e9826b4d86f0387e5
Source noteuspto-grants-2003_10