HRID988209

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID22135432

4-(6-Aminopyridin-3-yl)-1,3-dihydroindol-2-one

C13H11N3O

结构：CCOC(=O)c1c(C)[nH]c(C=O)c1CCCN1CCN(C)CC1

HCID58779587

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)c1c(C)[nH]c(C=C2C(=O)Nc3cccc(-c4ccc(N)nc4)c32)c1CCCN1CCN(C)CC1

HCID69584160

未命名化合物

PROCEDURE

实验过程

4-(6-Aminopyridin-3-yl)-1,3-dihydroindol-2-one (56 mg, 0.25 mmol) was condensed with 5-formyl-2-methyl-4-[3-(4-methyl-piperazin-1-yl)propyl]-1H-pyrrole-3-carboxylic acid ethyl ester (88 mg, 0.275 mmol) to give the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4adffc920fdd4765802f1a98949d151d
来源数据集: uspto-grants-2003_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06635640B2
来源说明: uspto-grants-2003_10

反应 SMILES

[NH2:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:16]=[CH:15][CH:14]=[C:13]3[C:9]=2[CH2:10][C:11](=[O:17])[NH:12]3)=[CH:4][CH:3]=1.[CH2:18]([O:20][C:21]([C:23]1[C:27]([CH2:28][CH2:29][CH2:30][N:31]2[CH2:36][CH2:35][N:34]([CH3:37])[CH2:33][CH2:32]2)=[C:26]([CH:38]=O)[NH:25][C:24]=1[CH3:40])=[O:22])[CH3:19]>>[CH2:18]([O:20][C:21]([C:23]1[C:27]([CH2:28][CH2:29][CH2:30][N:31]2[CH2:36][CH2:35][N:34]([CH3:37])[CH2:33][CH2:32]2)=[C:26]([CH:38]=[C:10]2[C:9]3[C:13](=[CH:14][CH:15]=[CH:16][C:8]=3[C:5]3[CH:6]=[N:7][C:2]([NH2:1])=[CH:3][CH:4]=3)[NH:12][C:11]2=[O:17])[NH:25][C:24]=1[CH3:40])=[O:22])[CH3:19]