Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | o-Toluenesulfonyl chloride | HCID 8623 | — |
| Reactant | HCID 69132345 | HCID 69132345 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 69132655 | HCID 69132655 | 10% |
Reaction Steps
A reaction mixture of compound B (0.05 g, 0.16 mmole; obtained from Example 14), toluenesulfonyl chloride (0.03 g, 0.16 mmole), and 50 mL of toluene was heated to 150° C. for 2 hr. Toluene was removed in vacuo to produce a residue. The residue was chromatographied using silica gel column with a developing solvent (CH2Cl2) to give 0.007 g (10%) of Compound 16.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06635649B2 |
|---|
| Source dataset | uspto-grants-2003_10 |
|---|
| ORD ID | ord-3970525b139b46ddb24dd3e74349e2cf |
|---|
| Source note | uspto-grants-2003_10 |
|---|
