4-(Quinolin-2-ylmethoxy)-butan-1-ol → {2-Methyl-6-[4-(quinolin-2-ylmethoxy)-butoxymethyl]-phenoxy}-acetonitrile

HRID 988265Notes

Reaction equation

HRID 988265 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][CH2:13][CH2:14][CH2:15][CH2:16][OH:17].Br[CH2:19][C:20]1[CH:29]=[CH:28][CH:27]=[C:26]([CH3:30])[C:21]=1[O:22][CH2:23][C:24]#[N:25]>>[CH3:19][C:20]1[CH:29]=[CH:28][CH:27]=[C:26]([CH2:30][O:17][CH2:16][CH2:15][CH2:14][CH2:13][O:12][CH2:11][C:2]2[CH:3]=[CH:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[N:1]=2)[C:21]=1[O:22][CH2:23][C:24]#[N:25]

Participants

3

Reactant 2

HCID 180080564-(Quinolin-2-ylmethoxy)-butan-1-olHCID 222414892-Cyanomethoxy-3-methylbenzyl bromide

Product 1

HCID 18008037{2-Methyl-6-[4-(quinolin-2-ylmethoxy)-butoxymethyl]-phenoxy}-acetonitrile

Procedure

MS (ESI) 391 (M+H)+. Prepared from 4-(quinolin-2-ylmethoxy)-butan-1-ol (EXAMPLE 34b) and (2-bromomethyl-6-methyl-phenoxy)-acetonitrile

Sources & evidence

ORD record
ord-866ef892044a456c9dda3df534c162c8
Source dataset
uspto-grants-2003_10
Patent number
US06635655B1

Reaction notes

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