2,2-Dimethyl-3-(quinolin-2-ylmethoxy)-propan-1-ol → {4-Chloro-2-[2,2-dimethyl-3-(quinolin-2-ylmethoxy)-propoxymethyl]-6-methyl-phenoxyl}-acetonitrile

HRID 988268Notes

Reaction equation

HRID 988268 reaction equation
[CH3:1][C:2]([CH3:18])([CH2:5][O:6][CH2:7][C:8]1[CH:17]=[CH:16][C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:9]=1)[CH2:3][OH:4].Br[CH2:20][C:21]1[CH:30]=[C:29]([Cl:31])[CH:28]=[C:27]([CH3:32])[C:22]=1[O:23][CH2:24][C:25]#[N:26]>>[Cl:31][C:29]1[CH:28]=[C:27]([CH3:32])[C:22]([O:23][CH2:24][C:25]#[N:26])=[C:21]([CH2:20][O:4][CH2:3][C:2]([CH3:18])([CH3:1])[CH2:5][O:6][CH2:7][C:8]2[CH:17]=[CH:16][C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[N:9]=2)[CH:30]=1

Participants

3

Reactant 2

HCID 180080462,2-Dimethyl-3-(quinolin-2-ylmethoxy)-propan-1-olHCID 22241394(2-Bromomethyl-4-chloro-6-methyl-phenoxy)-acetonitrile

Product 1

HCID 18008085{4-Chloro-2-[2,2-dimethyl-3-(quinolin-2-ylmethoxy)-propoxymethyl]-6-methyl-phenoxyl}-acetonitrile

Procedure

MS (ESI) 439 (M+H)+. Prepared from 2,2-dimethyl-3-(quinolin-2-ylmethoxy)-propan-1-ol (EXAMPLE 34e) and (2-bromomethyl-4-chloro-6-methyl-phenoxy)-acetonitrile.

Sources & evidence

ORD record
ord-1a1c6a6d72934e9991e27707a2858523
Source dataset
uspto-grants-2003_10
Patent number
US06635655B1

Reaction notes

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