反应详情

Sodium hydride (60% in mineral oil, 40 mg, 1.0 mmol) and 1-(3,4-methylenedioxyphenyl)-2-[5-(3,4-dimethoxyphenyl)-pyrimidin-2-yl]-2,3,4,9-tetrahydro-1H-β-carboline (218 mg, 0.43 mmol) (prepared as in Example 13) in DMF (10 mL, anhydrous) were stirred at room temperature for 30 min. Dry air was then bubbled through the solution for 16 h. Ethyl acetate (100 mL) and saturated NaHCO3 were added, the organic phase was washed with water, brine, and dried with MgSO4. Solvent was evaporated and the residue purified by chromatography (silica gel, ethyl acetate) to yield the product as a white solid.

1. customDry air
2. customwas then bubbled through the solution for 16 h
3. additionEthyl acetate (100 mL) and saturated NaHCO3 were added
4. washthe organic phase was washed with water, brine
5. dry with materialdried with MgSO4
6. customSolvent was evaporated
7. customthe residue purified by chromatography (silica gel, ethyl acetate)