1,4-Dioxane → 1,3Dioxol-5-yl-2-(4-imidazol-1-yl-phenyl)-1,2,3,4-tetrahydro-pyrrolo[3,4-b]quinolin-9-one

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	1,4-Dioxane	HCID 31275	—
Edukt	2-(Di-tert-butylphosphino)biphenyl	HCID 2734215	—
Edukt	1-(4-Bromophenyl)imidazole	HCID 2735604	—
Edukt	3-(1,3-benzodioxol-5-yl)-1,2,3,4-tetrahydro-9H-pyrrolo[3,4-b]quinolin-9-one	HCID 10892121	—
Edukt	Sodium t-butoxide	HCID 23676156	—
Katalysator	Bis(dibenzylideneacetone)palladium	HCID 9811564	—
Produkt	1,3Dioxol-5-yl-2-(4-imidazol-1-yl-phenyl)-1,2,3,4-tetrahydro-pyrrolo[3,4-b]quinolin-9-one	HCID 86759221	—

Reaktionsschritte

3-(1,3-benzodioxol-5-yl)-1,2,3,4-tetrahydro-9H-pyrrolo[3,4-b]quinolin-9-one (30.6 mg, 0.1 mmol), 1-(4-bromo-phenyl)-1H-imidazole (22.3 mg, 0.1 mmol), Pd2dba3 (4.6 mg, 0.005 mmol), biphenyl-2-yl-di-tert-butyl-phosphane 3.0 mg, 0.01 mmol) and NaOtBu (14 mg, 0.14 mmol) were stirred in 1,4-dioxane (0.6 mL) at 89° C. for 17 hours. Purification by preparative TLC (5% CH3OH/CH2Cl2) yielded the title product as yellow powder.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US06635638B2
Quelldatensatz	uspto-grants-2003_10
ORD ID	ord-40c5ab01addc4ce28732d453c29abdb5
Quellennotiz	uspto-grants-2003_10