(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid → 1-(N'-(3,5-Difluorophenylacetyl)-L-alaninyl)amino 3-methyl-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one

Participants

Reaction Steps

Following General Procedure A above using N-(3,5-difluorophenylacetyl)-L-alanine (Example B) and 1-amino-3-methyl-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one, the title compound was prepared. The reaction was monitored by tlc on silica gel (Rf=0.15 in ethyl acetate) and purification was by flash chromatography using ethyl acetate as the eluant.

Provenance & Evidence