huagongshe.com
HRID988435

反应详情

EQUATION

反应方程式

HRID 988435 的结构方程式

REACTANTS

反应物

2
结构：O=C(O)Cc1cc(F)cc(F)c1
HCID145424

3,5-Difluorophenylacetic acid

C8H6F2O2

结构：C[C@H](N)C(=O)C1(N)C(=O)N(C)c2ccccc2N(C)C1=O.Cl
HCID69033234

未命名化合物

PRODUCTS

生成物

1
结构：C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)NC1C(=O)N(C)c2ccccc2N(C)C1=O
HCID22984083

未命名化合物

PROCEDURE

实验过程

Following General Procedure I above using 3,5-difluorophenylacetic acid (Lancaster) and 3-(L-alaninyl)-amino-2,4-dioxo-1,5-bis-methyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine hydrochloride (Example 8-R), the title compound was prepared as a white solid (melting point=206-207° C.). Purification was by flash chromatography eluting with straight EtOAc gradient to EtOAc/Acetone (95:5). Rf=0.32 (EtOAc).

WORKUP

后处理

  1. customPurification
  2. washeluting with straight EtOAc gradient to EtOAc/Acetone (95:5)