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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 988464Generated: October 26, 2026

Ethyl pyruvate → N-(3,4Difluorophenyl)alanine Ethyl Ester

https://huagongshe.com/reaction/988464

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl pyruvateHCID 12041—
Reactant3,4-DifluoroanilineHCID 77469—
ProductN-(3,4Difluorophenyl)alanine Ethyl EsterHCID 15434838—

Reaction Steps

Following General Procedure AA above and using 3,4-difluoroaniline (Aldrich) and ethyl pyruvate (Aldrich), the title compound was prepared. The reaction was monitored by tlc on silica gel (Rf=0.4 in 25% EtOAc/hexanes) and purification was by preparative plate chromatography (silica gel using 25% EtOAc/hexanes as the eluant).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06635632B1
Source datasetuspto-grants-2003_10
ORD IDord-2154936fd79a4a06875fd264f55e8a8d
Source noteuspto-grants-2003_10