HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Naphthylamine → N-(2-naphthyl)alanine Ethyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Naphthylamine | HCID 7057 | — |
| Reactant | Ethyl pyruvate | HCID 12041 | — |
| Product | N-(2-naphthyl)alanine Ethyl Ester | HCID 11345542 | — |
Reaction Steps
Following reductive amination General Procedure AA above and using 2-aminonaphthalene (Aldrich) and ethyl pyruvate (Aldrich), the title compound was prepared as a solid having a melting point of 52-56° C. The reaction was monitored by silica gel tlc (Rf=0.50 in 25% EtOAc/hexanes). Purification was by flash chromatography with silica gel using 25% EtOAc/hexanes as the eluant.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06635632B1 |
| Source dataset | uspto-grants-2003_10 |
| ORD ID | ord-5d1b5eb7a2bb478e90ed9afd060181a1 |
| Source note | uspto-grants-2003_10 |