2-(3-Methyl-1,2-oxazol-5-yl)acetic acid → N-[(3-methylisoxazol-5yl)acetyl]alanine Iso-butyl Ester

HRID 988539Notes

Reaction equation

HRID 988539 reaction equation
[CH3:1][C:2]1[CH:6]=[C:5]([CH2:7][C:8]([OH:10])=O)[O:4][N:3]=1.[CH2:11]([O:15][C:16](=[O:20])[C@H:17]([CH3:19])[NH2:18])[CH:12]([CH3:14])[CH3:13]>>[CH2:11]([O:15][C:16](=[O:20])[C@H:17]([CH3:19])[NH:18][C:8](=[O:10])[CH2:7][C:5]1[O:4][N:3]=[C:2]([CH3:1])[CH:6]=1)[CH:12]([CH3:14])[CH3:13]

Participants

3

Reactant 2

HCID 41955322-(3-Methyl-1,2-oxazol-5-yl)acetic acidHCID 137435562-methylpropyl (2S)-2-aminopropanoate

Product 1

HCID 15481782N-[(3-methylisoxazol-5yl)acetyl]alanine Iso-butyl Ester

Procedure

Following General Procedure BI above, and using (3-methyl-isoxazol-5-yl)acetic acid (CAS #19668-85-0) and alanine iso-butyl ester (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-6666f2c7f2c2409481f23e5640203ec7
Source dataset
uspto-grants-2003_10
Patent number
US06635632B1

Reaction notes

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