HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 1-(4-Pyridinyl)-4-piperidinecarbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 1-(Pyridin-4-yl)piperidine-4-carboxylic acid | HCID 1268289 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(4-Pyridinyl)-4-piperidinecarbonyl chloride | HCID 11183700 | — |
Reaction Steps
To a stirring suspension of 1-(4-pyridinyl)piperidin-4-ylcarboxylic acid (0.8 g, 3.88 mmol) in dichloromethane (75 mL) at reflux was added thionyl chloride (0.45 mL, 5.82 mmol). After 3 h, the solvent was removed in vacuo and the residue was dissolved in dichloromethane (75 mL), giving a solution of the title compound, approximately 0.05 M.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06635657B1 |
| Source dataset | uspto-grants-2003_10 |
| ORD ID | ord-0f868e63331b46a2a295c8e3477a2427 |
| Source note | uspto-grants-2003_10 |