反应详情

To a stirred solution of methyl 1-Boc-1,2,3,6-tetrahydro-4-pyridinecarboxylate (2.22 g, 9.2 mmol) in methanol (10 mL) was added 1.0 N aqueous sodium hydroxide (25 mL). After stirring for 2 h, the solvent was removed in vacuo. The residue was partitioned between diethyl ether and water, and the layers were separated. The aqueous phase was acidified to pH 2.5 with concentrated hydrochloric acid and extracted with ethyl acetate. The organic extract was washed with saturated aqueous sodium chloride, dried (magnesium sulfate), filtered, and concentrated in vacuo to give 1.62 g (78%) of the title compound as a white solid.

1. customthe solvent was removed in vacuo
2. customThe residue was partitioned between diethyl ether and water
3. customthe layers were separated
4. extractionextracted with ethyl acetate
5. extractionThe organic extract
6. washwas washed with saturated aqueous sodium chloride
7. dry with materialdried (magnesium sulfate)
8. filtrationfiltered
9. concentrationconcentrated in vacuo