HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acrylonitrile → HCID 21906236, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acrylonitrile | HCID 7855 | — |
| Reactant | 2-[(1-tert-butoxycarbonylpiperidin-4-ylcarbonyl)amino]-N-(5-chloropyridin-2-yl)-5-iodobenzamide | HCID 21906635 | — |
| Product | HCID 21906236 | HCID 21906236 | 48% |
Reaction Steps
Using methods substantially equivalent to those described in Example 259-A, 2-[(1-tert-butoxycarbonylpiperidin-4-ylcarbonyl)amino]-N-(5-chloropyridin-2-yl)-5-iodobenzamide was condensed with acrylonitrile. From the reaction mixture was isolated (E)-2-[(1-tert-butoxycarbonylpiperidin-4-ylcarbonyl)amino]-N-(5-chloropyridin-2-yl)-5-(2-cyanovinyl)benzamide (0.49 g, 48%), as well as the (Z)-isomer (see next example).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06635657B1 |
| Source dataset | uspto-grants-2003_10 |
| ORD ID | ord-23e605520873443d9d1b962a23cd4040 |
| Source note | uspto-grants-2003_10 |