HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → n-(5-Chloropyridin-2-yl)-2-[[1-(1-isopropylpiperidin-4-yl)ethyl]amino]-4-methoxycarbonylbenzamide trihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | tert-Butyl 4-(2-oxoethyl)piperidine-1-carboxylate | HCID 10353694 | — |
| Reactant | 2-amino-N-(5-chloropyridin-2-yl)-4-methoxycarbonylbenzamide | HCID 21906318 | — |
| Product | n-(5-Chloropyridin-2-yl)-2-[[1-(1-isopropylpiperidin-4-yl)ethyl]amino]-4-methoxycarbonylbenzamide trihydrochloride | HCID 21906269 | 61% |
Reaction Steps
Using a similar procedure to that described in Example 47-C, 2-amino-N-(5-chloropyridin-2-yl)-4-methoxycarbonylbenzamide (2.7 g, 8.8 mmol) and 1-(tert-butoxycarbonyl)piperidine-4-acetaldehyde (3.0 g, 13 mmol) afforded, after trituration with EtOAc:methylene chloride, 2.8 g (61%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06635657B1 |
| Source dataset | uspto-grants-2003_10 |
| ORD ID | ord-5822396de616434d988ab97a2d8a5594 |
| Source note | uspto-grants-2003_10 |