Stavudine → Stavudine DMA

Participants

Reaction Conditions

Reaction Steps

Crude white Stavudine (12.10 g, 94.25% pure, 0.0509 mole) was combined with DMA (18.15 g, 1.5 parts) and acetone (36 mL) and heated to 56° C. when all solids had dissolved. The cloudy mixture was filtered, distilled to remove acetone, cooled, filtered, washed with acetone and dried to give 12.35 g of white Stavudine-DMA solvate (0.0397 mole, 78.1%) with a chromatographic purity of 99.35%.

Provenance & Evidence