Water → Stavudine

참여 물질

반응 조건

반응 단계

The Stavudine-DMA solvate (15.22 g, 0.0489 mole), water (5.5 g) and isopropanol (150 mL) were combined and heated to about 70° C. when all solids had dissolved to give a clear colourless solution, heating was continued so as to distill the solution at atmospheric pressure until about 35 mL of isopropanol remained. The solution was allowed to cool on its own with agitation and a mass of crystals formed after 20 minutes. The mixture was 10 placed on an ice-water bath for I hour, filtered, washed with isopropanol (2×11 mL) and air dried overnight to give 10.02 g (0.0447 mole, 91.4%) of pure white crystalline Stavudine. The HPLC results are given in Table 2.

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