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Methoxyacetyl chloride → methoxyacetic acid N-(1-Boc-piperidin-3-ylmethyl)-N-phenylamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methoxyacetyl chloride | HCID 96623 | — |
| 反応物 | N-(1-Boc-piperidin-3-ylmethyl)aniline | HCID 12972131 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | methoxyacetic acid N-(1-Boc-piperidin-3-ylmethyl)-N-phenylamide | HCID 53812669 | 56% |
反応手順
To a stirred suspension of N-(1-Boc-piperidin-3-ylmethyl)-aniline 4 (101 mg, 0.348 mmol) and piperidinomethyl polystyrene resin (110 mg) in 2 mL of dry CH2Cl2 was added methoxyacetyl chloride (97%, 34 μL, 1.05 eq.) at room temperature. After being shaken at room temperature for 4 hours, the reaction mixture was passed through an aminopropyl NH2 cartridge and washed with CH2Cl2 Removal of CH2Cl2 afforded methoxyacetic acid N-(1-Boc-piperidin-3-ylmethyl)-N-phenylamide 38 (70 mg, 56%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06635661B2 |
| 出典データセット | uspto-grants-2003_10 |
| ORD ID | ord-8d86da9305c54ae48615c59477221aa9 |
| 出典メモ | uspto-grants-2003_10 |