HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nitric Acid → HCID 2794458, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nitric Acid | HCID 944 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 6,7-Dimethoxy-4-(trifluoromethyl)quinolin-2(1H)-one | HCID 2794425 | — |
| Reactant | Propan-2-one--dichloromethane (1/1) | HCID 21584124 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 2794458 | HCID 2794458 | 70% |
Reaction Steps
3.5 g of 6,7-dimethoxy-4-trifluoromethyl-2-(1H)-quinolone are nitrated with 50 ml of a semi-concentrated mixture of nitric acid and sulphuric acid under ice cooling. The mixture is heated to room temperature and poured on water. The precipitation formed is cleaned with Flash Chromatography (silica gel, dichloromethane:acetone 9:1). Yield 70%, melting point 270° C., UV λ max 391 nm (DMSO), IR (KBR) CO: 1670cm-1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06635759B2 |
| Source dataset | uspto-grants-2003_10 |
| ORD ID | ord-150651710ba34116b274200bca9a0446 |
| Source note | uspto-grants-2003_10 |