Toluene → HCID 9817790, compound

HRID 988818Notes

Reaction equation

HRID 988818 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([C:14]([F:17])([F:16])[F:15])=[CH:8][C:9](=[O:13])[NH:10]2)=[CH:5][C:4]=1[NH2:18].[C:19](OC(=O)C)(=[O:21])[CH3:20].C1(C)C=CC=CC=1.CC(C)=O.C1(C)C=CC=CC=1>C(O)(=O)C>[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([C:14]([F:15])([F:16])[F:17])=[CH:8][C:9](=[O:13])[NH:10]2)=[CH:5][C:4]=1[NH:18][C:19](=[O:21])[CH3:20]

Participants

6

Reactant 4

HCID 1140TolueneHCID 7918Acetic AnhydrideHCID 2794444HCID 2794444, compoundHCID 20247278Toluene acetone

Product 1

HCID 9817790HCID 9817790, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

27,85 mg of 7-methoxy-6-amino-4-trifluoromethyl-2-(1H)-quinolone are dissolved in 0,5 ml of glacial acetic acid, mixed with 0.15 ml acetic acid anhydride and made to react for 2 hours at 20° C. After subtracting the solvent, the remainder is cleaned with Flash chromatography (silica gel, toluene/acetone 1:1). Yield: 30.7 mg (99%). Melting point 280° C. (toluene, dec), UV λ max 368 nm, emission max 448 nm, IR 1680 (CO).

Workup

  1. customto react for 2 hours at 20° C

Sources & evidence

ORD record
ord-770130fca33544adade439e9863d73b6
Source dataset
uspto-grants-2003_10
Patent number
US06635759B2

Reaction notes

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