N-Iodosuccinimide → 6-Chloro-7-iodo-7-deazapurine

Participants

Reaction Steps

To a stirred solution of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine (30 g/0.02 mol) dissolved in 80 mL of chloroform was added 4.5 grams (0.02 mol) of N-iodosuccinimide and the resulting mixture heated at reflux for 1 hour. After cooling to room temperature, the percipitate was removed by filtration and dried under reduced pressure affording 4.6 grams (82%) of the title compound.

Provenance & Evidence