反应详情

温度

20 °C

2.1 g (+)-Methyl (2-chlorophenyl)-(6,7-dihydro-4H-thieno[3,2-c]pyrid-5-yl)acetate was added 7.6 mL of acetone to obtain a clear solution. To this solution, 0.887 g of H2SO4 (80%) was added slowly and temperature was maintained around 20° C. under nitrogen atmosphere. Later the reaction mixture was cooled upto −20° C. for 2 hrs and then the temperature was brought to room temperature (20° C.). The reaction mixture was stirred at 20-25° C. Precipitate was isolated (600 mg), dried under vacuum at temperature not exceeding 50° C.

1. customto obtain a clear solution
2. temperatureLater the reaction mixture was cooled upto −20° C. for 2 hrs
3. customwas brought to room temperature
4. custom(20° C.)
5. customPrecipitate was isolated (600 mg)
6. customdried under vacuum at temperature not
7. customexceeding 50° C.