2-Naphthalenesulfonyl chloride → HCID 10129518, compound

HRID 988882Notes

Reaction equation

HRID 988882 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[N:5]([CH:27]([C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:6]2[C:11]([C:12]=1[CH2:13][CH2:14][O:15][C:16]1[CH:25]=[CH:24][C:19]([C:20]([O:22]C)=[O:21])=[CH:18][CH:17]=1)=[CH:10][C:9]([Cl:26])=[CH:8][CH:7]=2.[CH:40]1[C:49]2[C:44](=[CH:45][CH:46]=[CH:47][CH:48]=2)[CH:43]=[CH:42][C:41]=1[S:50](Cl)(=[O:52])=[O:51]>>[CH:27]([N:5]1[C:6]2[C:11](=[CH:10][C:9]([Cl:26])=[CH:8][CH:7]=2)[C:12]([CH2:13][CH2:14][O:15][C:16]2[CH:17]=[CH:18][C:19]([C:20]([OH:22])=[O:21])=[CH:24][CH:25]=2)=[C:4]1[CH2:3][CH2:2][NH:1][S:50]([C:41]1[CH:42]=[CH:43][C:44]2[C:49](=[CH:48][CH:47]=[CH:46][CH:45]=2)[CH:40]=1)(=[O:52])=[O:51])([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[C:34]1[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=1

Participants

3

Reactant 2

HCID 71252-Naphthalenesulfonyl chlorideHCID 16116212HCID 16116212, compound

Product 1

HCID 10129518HCID 10129518, compoundYield 53%

Procedure

To the methyl 4-{2-[2-(2-aminoethyl)-1-benzhydryl-5-chloro-1H-indol-3-yl]ethoxy}benzoate (Step 5, Example 1)was added 2-naphthalenesulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 53% yield.

Sources & evidence

ORD record
ord-9c668c2e192b40eea111d9b1f1781353
Source dataset
uspto-grants-2003_10
Patent number
US06635771B2

Reaction notes

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