Benzenesulfonyl chloride, 3,4-dichloro- → HCID 10240444, compound

HRID 988884Notes

Reaction equation

HRID 988884 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[N:5]([CH:27]([C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:6]2[C:11]([C:12]=1[CH2:13][CH2:14][O:15][C:16]1[CH:25]=[CH:24][C:19]([C:20]([O:22]C)=[O:21])=[CH:18][CH:17]=1)=[CH:10][C:9]([Cl:26])=[CH:8][CH:7]=2.[Cl:40][C:41]1[CH:42]=[C:43]([S:48](Cl)(=[O:50])=[O:49])[CH:44]=[CH:45][C:46]=1[Cl:47]>>[CH:27]([N:5]1[C:6]2[C:11](=[CH:10][C:9]([Cl:26])=[CH:8][CH:7]=2)[C:12]([CH2:13][CH2:14][O:15][C:16]2[CH:17]=[CH:18][C:19]([C:20]([OH:22])=[O:21])=[CH:24][CH:25]=2)=[C:4]1[CH2:3][CH2:2][NH:1][S:48]([C:43]1[CH:44]=[CH:45][C:46]([Cl:47])=[C:41]([Cl:40])[CH:42]=1)(=[O:50])=[O:49])([C:34]1[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=1)[C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1

Participants

3

Reactant 2

HCID 7383Benzenesulfonyl chloride, 3,4-dichloro-HCID 16116212HCID 16116212, compound

Product 1

HCID 10240444HCID 10240444, compoundYield 60%

Procedure

To the methyl 4-{2-[2-(2-aminoethyl)-1-benzhydryl-5-chloro-1H-indol-3-yl]ethoxy}benzoate (Step 5, Example 1)was added 3,4-dichlorobenzenesulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 60% yield.

Sources & evidence

ORD record
ord-1fa6a6ac64514bfd91a5361fad248254
Source dataset
uspto-grants-2003_10
Patent number
US06635771B2

Reaction notes

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