HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenylmethanesulfonyl chloride → 4-[[2-(1-benzhydryl-2-{2-[(benzylsulfonyl)amino]ethyl}-5-chloro-1H-indol-3-yl)ethyl](methyl)amino]benzoic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenylmethanesulfonyl chloride | HCID 74740 | — |
| Reactant | 4-({2-[2-(2-Amino-ethyl)-1-benzhydryl-5-chloro-1H-indol-3-yl]-ethyl}methyl-amino)-benzoic acid methyl ester | HCID 20598525 | — |
| Product | 4-[[2-(1-benzhydryl-2-{2-[(benzylsulfonyl)amino]ethyl}-5-chloro-1H-indol-3-yl)ethyl](methyl)amino]benzoic Acid | HCID 21962456 | 83% |
Reaction Steps
The intermediate from step 7 was treated with α-toluenesulfonyl chloride according to the procedure in Example 87 step 2 to generate the desired product in 83% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06635771B2 |
| Source dataset | uspto-grants-2003_10 |
| ORD ID | ord-973b5c6a02934ade93b344975f2509e2 |
| Source note | uspto-grants-2003_10 |