Benzene, 1-fluoro-2-methyl-4-nitro- → HCID 18003869, compound

HRID 988918Notes

Reaction equation

HRID 988918 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[CH3:11].[N:12]1([CH2:17][CH2:18][CH2:19][NH2:20])[CH:16]=[CH:15][N:14]=[CH:13]1>>[N:12]1([CH2:17][CH2:18][CH2:19][NH:20][C:2]2[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=2[CH3:11])[CH:16]=[CH:15][N:14]=[CH:13]1

Participants

3

Reactant 2

HCID 68001Benzene, 1-fluoro-2-methyl-4-nitro-HCID 787361H-Imidazole-1-propanamine

Product 1

HCID 18003869HCID 18003869, compoundYield 44.2%

Conditions

Temperature
96 °C

Procedure

Starting with 31.2 g (0.2 mol) of 1-fluoro-2-methyl-4-nitrobenzene and 37.5 g (0.3 mol) of 3-imidazol-1-ylpropylamine, and after purification by recrystallization from refluxing 96° C. ethanol, 23.0 g of orange-yellow crystals melting at 163° C. (Kofler) were obtained, the elemental analysis of which, calculated for C13H16N4O2.¼H2O, was:

Workup

  1. customafter purification
  2. customby recrystallization

Sources & evidence

ORD record
ord-6b7dca5f5acb40a6a3671b99df3b5744
Source dataset
uspto-grants-2003_10
Patent number
US06638321B1

Reaction notes

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