HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 988919Generated: October 30, 2026
1H-Imidazole-1-propanamine → (2-Fluoro-4-nitrophenyl)-(3-imidazol-1-ylpropyl)amine
https://huagongshe.com/reaction/988919
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1H-Imidazole-1-propanamine | HCID 78736 | — |
| Reactant | 1,2-Difluoro-4-nitrobenzene | HCID 123053 | — |
| Product | (2-Fluoro-4-nitrophenyl)-(3-imidazol-1-ylpropyl)amine | HCID 18003903 | 68.1% |
Reaction Steps
Starting with 31.8 g (0.2 mol) of 1,2-difluoro-4-nitrobenzene and 37.5 g (0.3 mol) of 3-imidazol-1-ylpropylamine, and after purification by recrystallization from refluxing 96° C. ethanol, 36.0 g of orange-yellow crystals melting at 144° C. (Kofler) were obtained, the elemental analysis of which, calculated for C12H13N4O2F, was:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06638321B1 |
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| Source dataset | uspto-grants-2003_10 |
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| ORD ID | ord-683554f75d7b4ccda1f521016a2017d4 |
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| Source note | uspto-grants-2003_10 |
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