Estradiol → Estradiol; Norethindrone Acetate

Participants

Reaction Steps

An estradiol/norethindrone acetate pressure-sensitive adhesive matrix composition was prepared by combining 0.7 parts of estradiol and 3.0 parts of norethindrone acetate along with 3.0 parts of ethyl cellulose (Ethocele® 10, Dow Chemical Corp., Midland, Mich.) in 30.0 parts ethyl acetate, 15.0 parts of toluene and 10.0 parts isopropyl alcohol. Then 12.2 parts of a polyacrylate adhesive (DURO-TAIE® 87-2510; National Starch Company, Bridgewater, N.J.) and 109.2 parts of a polysiloxane adhesive (BIO-PSA® Q7-4603; Dow Corning Corp, Midland, Mich.) were added and thoroughly mixed. Finally 9.0 parts of dipropylene glycol and 6.0 parts oleyl alcohol were added and mixed thoroughly in an appropriate container until the mixture was completely homogenous. The resulting composition had the ingredient concentrations on a dry weight percent basis (i.e., after evaporation of volatile solvents) as shown below.

Provenance & Evidence