反应详情

Freshly distilled acrylonitrile (2.5 g) is added to a solution of 3 g of 2-benzyl-2,5-diazabicyclo [2.2.1]heptane in 40 mL of anhydrous toluene and refluxed with vigorous stirring. The solution was cooled, filtered and evaporated. Bulb tube distillation (boiling point: 120°-130° C. at 0.01 mbar) resulted in 3.43 g of 142 as a colorless oil (88% of the theoretical yield).

1. temperaturerefluxed with vigorous stirring
2. temperatureThe solution was cooled
3. filtrationfiltered
4. customevaporated
5. distillationBulb tube distillation (boiling point: 120°-130° C. at 0.01 mbar)