Methane → HCID 86585962, compound

Participants

Reaction Steps

A pre-cooled solution of diphosgene (168.0 mmol) in ethyl acetate was added dropwise via addition funnel into the cold solution of 4-(t-butyl)cyclohexylamine (140.0 mmol) and charcoal (catalytic) in ethyl acetate at −10C. After the addition, the reaction was heated to reflux overnight, and filtered through a Celite plug. The solution was concentrated to give a thick oil, which was distilled in vacuo to yield 4-(tert-butyl)cyclohexanisocyanate as a clear liquid (48%).

Provenance & Evidence