7-Bromo-4-(trifluoromethyl)benzofuran → HCID 20598788, compound

HRID 989011Notes

Reaction equation

HRID 989011 reaction equation
[F:1][C:2]([F:14])([F:13])[C:3]1[C:8]2[CH:9]=[CH:10][O:11][C:7]=2[C:6](Br)=[CH:5][CH:4]=1.[C:15]([O:19][C:20]([N:22]1[CH2:27][CH2:26][NH:25][CH2:24][C@@H:23]1[CH2:28][CH3:29])=[O:21])([CH3:18])([CH3:17])[CH3:16]>>[F:1][C:2]([F:14])([F:13])[C:3]1[C:8]2[CH:9]=[CH:10][O:11][C:7]=2[C:6]([N:25]2[CH2:26][CH2:27][N:22]([C:20]([O:19][C:15]([CH3:17])([CH3:16])[CH3:18])=[O:21])[C@@H:23]([CH2:28][CH3:29])[CH2:24]2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 121147077-Bromo-4-(trifluoromethyl)benzofuranHCID 17750462(S)-2-Ethylpiperazine, N1-BOC protected

Product 1

HCID 20598788HCID 20598788, compoundYield 84%

Procedure

Beginning with 1.45 gm (5.47 mMol) 4-trifluoromethyl-7-bromobenzofuran and 1.4 gm (6.53 mMol) 1-(tert-butoxycarbonyl)-2(S)-ethylpiperazine, 1.82 gm (84%) of the desired compound were prepared essentially as described in Example 1.

Sources & evidence

ORD record
ord-07f8776c6ff24eeaa8419296887e896f
Source dataset
uspto-grants-2003_10
Patent number
US06638936B1

Reaction notes

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